HSCT

The central nervous system or (CNS) is part of the body's communication system. It is made up of the brain, spinal cord and the optic nerve, which mostly consist of nerve cells called neurons. Electrical signals travel along the neurons in the CNS carrying messages to all parts of the body. Nerve fibres known as axons are the part of the neuron that pick up electrical signals and deliver to the next neuron. Most axons are wrapped tightly in a white fatty material called a myelin sheath. This acts like insulation, allowing the electrical signals to travel rapidly without being interrupted or distorted.
 
Demyelination is damage caused to myelin by recurrent attacks of inflammation. Demyelination results in nervous system scars, called lesions which interrupt communication between the nerves and the rest of the body.
 
Its a little bit like your electricity in your house sometimes you need an Electrician to fix it.

 myelin

Stem Cell Transplants
There is currently only one scientifically-demonstrated & confirmed treatment for Multiple Sclerosis with enduring curative efficacy:Hematopoietic Stem Cell Transplantation (HSCT). This is not a new medical procedure; it has been performed millions of times all around the world since the 1960′s for treatment of cancer (now approximately 50,000 times per year) and has been used successfully to cure several types of hematologically-rooted autoimmune disorders since the early 1990′s (such as MS, scleroderma, rheumatoid arthritis, lupus, CIDP and others). It involves chemotherapy so the treatment is both uncomfortable and expensive (most medical insurance will not yet cover it for treatment of an autoimmune disorder until the phase III clinical trial is completed).


It is not an impossible procedure to endure, as many people do it and make it through just fine. But this procedure is currently the ONLY treatment that has been scientifically verified to stop the underlying MS disease process, restore normal immune self-tolerance and produce lasting curative symptomatic improvement for the majority of MS patients, as it has for me and others. And definitely worth mentioning. . . . probably one of the biggest intangible benefits to stopping the MS disease progression is that this treatment restores a degree of certainty to the future of a person’s life that MS often robs us of.


How & why does HSCT cure multiple sclerosis?


As a curative treatment HSCT works by partially or completely erasing the body’s immune system memory. This effects a beneficial change of the body’s overall B- and T-lymphocyte epitope (antigen binding)repertoire, inactivating autoimmunity (making the body’s immune cells “antigen naive”) which results in restoration of immune self tolerance. This is often referred to as “resetting” the immune system which stops the underlying MS disease activity & progression. Once achieved, the body then has a chance to repair (or compensate for) existing neural damage that is not undermined by further MS disease progression, often resulting in substantial and lasting symptomatic improvement.


The interesting fact here is that it is the chemotherapy which is effecting the curative aspect of the treatment by wiping out long-lived T- and B-lymphocytes of the body that carry the faulty autoreactive memory so they may be replaced by naive, unprogrammed and self-tolerant non-autoreactive lymphocytes generated by the bone marrow. The takeaway concept here is no chemotherapy = no cure. This is why simply injecting stem cells into the body does not render the body’s immune system self-tolerant as is required to stop the underlying MS disease activity.

STEPS:
Mobilization
For approximately four days (twice a day), I will be given injections to stimulate my stem cell growth.  The process of causing greater numbers of stem cells to be present in the blood stream in order for collection, is known as mobilization.   The most common side effect of  the mobilization process is mild-to-moderate bone pain or fever, which can often be controlled with Tylenol.


Apheresis (Collection of Stem Cells)
Apheresis is normally a painless procedure, however, back and hip pain have been reported.  The collection of stem cells takes approximately two to four hours for the procedure.  My blood will be withdrawn through a catheter and circulated through a cell-separating machine.  This machine separates and collects white blood cells, including the stem cells, along with a few red blood cells and platelets.  The remaining blood cells will be returned to my body.  There is only a small amount (several cups) of your blood in the separator machine at any one time.  Your blood is returned to you at the same rate it is removed.   After the cells are collected, they are frozen and stored under special conditions until they are needed for my transplant.


Chemotherapy
Approximately four days of chemotherapy will be utilized to wipe out my existing immune system.  Bloodwork will determine when the immune system has been sufficiently “shut down” in preparation for the stem cell transplant.  At this point, the status of my isolation will be raised and only doctors and nurses will be permitted to enter my room.


Stem Cell Transplant
After the high-dose chemotherapy is completed, my own stem cells will be given back to me.  There are few side effects to this procedure.  It is very much like a blood transfusion. You may notice some chilling, nausea, fever, cough, flushing, headache, abdominal cramps or diarrhea.  The nurses will give me medication to decrease these effects.
Although a stem cell transplant sounds dramatic, the actual procedure is simple. The stored frozen cells will be thawed in warm water, and infused back into my body.


Engraftment
One to three weeks following my transplant, signs that my stem cells/new immune sytem are growing (engrafting) and beginning to produce blood cells are expected.  This “new” immune system will have no memory of MS.  As this starts to occur, I may notice aching in my bones, especially my pelvis, lower back and thighs.  As my blood counts begin to rise, my white blood cells will start to fight and prevent infections.  Soon after this occurs, I will be released from the hospital.


Recovery
It takes an average of 12-18 months to see the complete benefits of this treatment, however, some patients have continued to see improvement for up to five years post-transplant.  In addition to halting the progression and activity of their MS, 80% of HSCT patients see a reversal of 45-80% of their pre-existing symptoms.

 Special thanks to George Goss (http://themscure.blogspot.com/)  Brooke Slick (http://msslickdotcom.wordpress.com)  and http://fromrussiawithlisa.wordpress.com/stem-cell-transplants/for the above listed information.